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Types Species and POI model Mechanisms Method of administration Outcome Reference iPSCs ICR mice differentiation function cultured and induced in vitro differentiate into oogonia gonocyte- like cells 69 BMSCs cyclophosphamide- induced ovarian failure in rabbits increased the secretion of VEGF injected intravenously in the ear veins reduced FSH level increased serum estrogen level and follicle number 70 BMSCs cisplatin- induced apoptosis of GCs aging rats downregulated P21 and Bax, upregulated the c- myc proto- oncogene mRNA co- culture in vitro injected via vena caudalis inhibited GCs apoptosis 71 ADSCs cisplatin- induced ovarian failure in mice induced angiogenesis intraovarian injected restored the number of ovarian follicles and corpus luteum 72 MenSCs epirubicin- induced GCs injury cisplatin- induced ovarian failure in mice protected GCs from apoptosis and increased secretion of fibroblast growth factor 2 co- culture in vitro injected via vena caudalis improved POI 73, 74 PMSCs the pZP3- induced POI mice model reduced follicular atresia and GCs apoptosis injected via vena caudalis increased serum AMH and estrogen levels 75 PMSCs the pZP3- induced POI mice model regulated Th17 Tc17 and Th17 Treg cell ratios by PI3K Akt signal pathway intraovarian injected restored ovarian function 76 PMSCs ovariectomized rat model upregulated antioxidant factors injected through the tail vein restored ovarian function 77 PMSCs the pZP3- induced POI mice model inhibited endoplasmic reticulum stress inositol- demanding enzyme 1 signaling pathway injected through the tail vein reduced GCs apoptosis 78 UC- MSCs cisplatin- induced ovarian failure in rat transform growth factor- ОІ Smad3 signaling pathway injected through the tail vein regulated the differentiation of ovarian stromal cells 79 AFSCs gilt differentiatived potential co- culture in vitro differentiated into primordial follicle oocytes in vitro 80 AMSCs cyclophosphamide- induced ovarian failure in rat reduced the expression of inflammatory cytokines injected through the tail vein inhibited ovarian inflammation 81 exosomal miR- 644- 5p derived from BMSCs cisplatin- induced ovarian failure in mice targeted the regulation of p53 injected through the tail vein suppressed GCs apoptosis 82 exosomal miR- 144- 5p derived from BMSCs cyclophosphamide- induced ovarian failure in rat target PTEN injected intraperitoneally inhibited GCs apoptosis 83 miR- 21 derived from BMSCs phosphamide mustard induced apoptosis of GCs cyclophosphamide- induced ovarian failure in rat downregulated PTEN and PDCD4 co- culture in vitro injected into the bilateral ovaries repaired ovarian structure and function 84 ADSC- derived exosomes cyclophosphamide- induced ovarian failure in mice regulated the SMAD pathway injected into the ovaries oogenesis and the proliferation of granular cells 85 exosomal miRNA- 17- 5p derived from hUC- MSCs cyclophosphamide- induced ovarian failure in mice regulated SIRT7 signaling pathway injected into the ovaries improved ovarian function 86 exosomal miR- 10a and miR- 146a derived from AFSCs cyclophosphamide- induced ovarian failure in mice inhibited follicular atresia transplanted into the ovaries increased GCs survival 87 exosomal miR- 320areleased from human AMSCs cyclophosphamide- induced ovarian failure in mice regulated Sirtuin4 injected into the ovaries delay ROS generation in POI 88 collagen caffold ADSCs tripterygium glycosides induced ovarian failure in rat enhance the retention of ADSCs in target organs injected into the ovaries increase follicle counts 89 collagen caffold UC- MSCs POI patients phosphorylation of FOXO3a and FOXO1 intraovarian injected activate follicles in dormant ovaries 90 alginate ADSCs mice secrete cytokines co- culture in vitro support follicle genesis, survival, and maturation in vitro 91 tamoxifen pregnant mice

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